JERINI


Research & Development Programs


Jerini is a leader in the systematic discovery and development of peptidomimetic and small molecule drugs derived from peptides.The company's Peptides-to-Drugs (P2D) technology platform facilitates the development of both peptidomimetic drugs (injectable), and small molecules (orally available) depending on the disease indication. Systematic program diversification balances the inherent risks and benefits associated with drug development and ensures significant opportunities for Jerini's future growth and increased company value.

Target (Compound) Partner Indication Discovery Preclinical Phase I Phase II Phase III Submisson
Bradykinin B2R (Icatibant) Hereditary Angioedema Hereditary angioedema
Bradykinin B2R (Icatibant) Drug-Induced Angioedema*
Bradykinin B2R (Icatibant) Capillary Leak Syndrome**
Bradykinin B2R (JSM-10292) Pain / Inflammation
C5aR (JSM-1375) Ophthalmology***
C5aR (JSM-7717) Inflammation
α5ß1 Integrin (JSM 6427) Ophthalmology***
α5ß1 Integrin (JSM-8757 Oncology
Bradykinin B1R (undisclosed) Pain / Inflammation
Undisclosed Alcon Ophthalmology
Undisclosed (Multiple Targets) Baxter Hemophilia
B2R:Bradykinin B2 Receptor *Phase II/III trial in drug-induced angioedema planned in 2008 **Icatibant is currently being tested in several preclinical Capillary Leak Syndrome models ***Ophthalmology compounds to be further developed by US-based Jerini Ophthalmic, Inc.
HAE-Network.info